BIG-IP APM supports Microsoft Windows 10 the same day it is released!   Support for Windows 10 in APM will be staggered, with BIG-IP v11.5.3 being the first version of F5 APM to offer support. Support will start via an BIG-IP Engineering HotFix made to customers when they go to https://downloads.f5.com.

BIG-IP Edge Client and Internet Explorer 11 will support client-based and clientless features, respectively. Support for Windows 10 in additional versions of BIG-IP will be available shortly; for specific versions, please refer to the F5 APM and Edge Client Support for Windows 10 AskF5 Solution, Windows 10 Support Notes, and BIG-IP APM Client Compatibility Matrix version 11.5.3