iRules still work but traffic doesn't get to pool - LTM v9

I have an outage that Im dealing with right now and it seems to resolve itself when an "update" is done. iRules still work on the VIP but connections get reset when traffic gets sent to pool. This occurs on VIPs that don't have iRules as well. It seems that a configuration change/update clears whatever problem the LTM has passing traffic to the pool. This appeared seemly "random".

 

 

Has anyone else had this happen?