irules-changes not reflecting

We are making updates to the irules but we do not see those changes getting reflected. Do we need to restart something after updating irules ? or changes should be dynamic ? Though we restarted the services from the Main-->services

 

Here is the irules. we are seeing content-type as 1.1 instead of 1.0

 

when HTTP_RESPONSE {

 

if { [PROFILE::http ramcache] equals 1 } {

 

CACHE::disable

 

}

 

HTTP::header remove Cache-Control

 

HTTP::header remove Expires

 

HTTP::header remove Pragma

 

if { [HTTP::header "Content-Type"] contains "application" } {

 

HTTP::version "1.0"

 

}

 

}

 

 

Thanks

 

Nimika