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What kind of configuration are you looking for? An iRule can change certain configuration on a virtual server, but it's not meant to do permanent configurations. Technically you could though by using iCall, but I would not recommend it. :)
For permanent configuration like adding pools or virtual servers you might want to look into TMSH commands, iControl or REST.
/Patrik
In that case I would look at TMSH commands (providing that you're still going to execute the changes manually). Or, if you want to automate, perhaps iControl. Until F5 fixes the mandatory admin access I would not recommend rest to anyone not using a intermediate XML/Rest proxy for security.
/Patrik