Firewall config for Skype for Business Reverse Proxy

Hey Everyone:

I recently completed setting up an edge pool for my Skype for Business 2015 deployment and all of my services are working as intended (IM/Presence and Video calls). I now wish to deploy reverse proxy services to allow mobile devices to connect externally. Fortunately for me I just so happen to have a Big IP in my DMZ and another Big IP in my internal network with my FE pool.

I am a bit confused about the ports that need to be open on different sides of the networks. I understand that the DMZ F5 is going to get it's own public IP address which will be NAT'd to my DMZ subnet where my DMZ F5 "lives". I understand also that I will specifically be NAT'ing TCP 80 and 443 to the Big IP.

Using the iApp I am going to have it forward reverse proxy traffic over to my internal Big IP which "lives" on my messaging subnet (just the subnet I have Skype and Exchange running on) and the internal will have the Skype iApp configured to receive the reverse proxy traffic from the DMZ Bip IP.

My question is, do I open ports 443 and 80 between the two Big IP's and then have 4443 and 8080 open between the internal Bip Ip and the FE pool? Or is there something I am missing where I'd open 4443 and 8080 between the two Big IP's (which I don't think is the case, just verifying).

Thanks all!