BigIQ 5.0/5.2 (Is there any impact when removing devices/services from BigIQ)

After (potentially) causing sync failures while adding bigIP devices to BigIQ after bringing LTMs online during a migration window, I'm pretty gunshy about doing anything in BigIQ outside a change window. But I'm looking to upgrade a couple of my BigIQ's to 5.3. Before I do, I want to remove all the BigIP devices that are in there so I can essentially start over on the new version. If I remove LTM service from a node in inventory management, and then in turn, remove the device itself from BigIQ, is there ANY potential to cause negative impact on the LTM itself?