HttpException on server with HTTP profile

might be best to post an anonymised output of your virtual server (tmsh list ltm virtual "name of virtual")

This is the output

root@(@@@@@@@@)(cfg-sync In Sync)(Active)(/Common)(tmos) list ltm virtual NAME_VS all-properties ltm virtual NAME_VS { address-status yes app-service none auth none auto-lasthop default bwc-policy none clone-pools none cmp-enabled yes connection-limit 0 description none destination 172.23.1.42:http enabled fallback-persistence none flow-eviction-policy none gtm-score 0 ip-protocol tcp last-hop-pool none mask 255.255.255.255 metadata none mirror disabled mobile-app-tunnel disabled nat64 disabled partition Common per-flow-request-access-policy none persist { Source_address_30min { default yes } } policies none pool NAME_POOL profiles { Analytics_Generic_TCP { context all } tcp-lan-optimized { context all } } rate-class none rate-limit disabled rate-limit-dst-mask 0 rate-limit-mode object rate-limit-src-mask 0 related-rules none rules none security-log-profiles none service-down-immediate-action none service-policy none source 0.0.0.0/0 source-address-translation { pool none type automap } source-port preserve syn-cookie-status not-activated traffic-classes none translate-address enabled translate-port enabled urldb-feed-policy none vlans none vlans-disabled vs-index 26 }

if you capture on the server itself, does the HTTP request look any different when the f5 does, and does not, apply a http profile?