At vmware level you will probably have mac issues as you indicate, but definitely at BIG-IP level you will have issues with licensing.
The BIG-IP VE is automatically configured during the first system boot with a unique REST device ID and secure shell (SSH) keys. When the BIG-IP VE is cloned these values become part of the cloned instance. In environments where multiple BIG-IP clone instances are run, the duplicate REST ID and SSH keys can cause access and management conflicts.
The cloned BIG-IP VE instance will have an identical /config/f5-rest-device-id key value of the original instance. BIG-IP VEs that are managed by a BIG-IQ system that shares the same f5-rest-device-id key value can cause a conflict regarding the BIG-IQ system's ability to discover or manage the BIG-IP VE clone instances.
The cloned BIG-IP VE instance will have identical SSH keys as the original instance, and may be presented as a security risk in some environments.
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Regards,