Jaked,
While it is technically possible to configure the BIG-IP to be a VXLAN VTEP (Virtual Tunneling End Point), it is recommended that you configure the F5 + NSX environment as per the Design and Best Practices Guide. (That's why I wrote them :)
If you choose to configure VXLAN on the BIG-IP you can refer to this section in the Implementations Guide to understand the steps to do so. https://support.f5.com/kb/en-us/products/big-ip_ltm/manuals/product/tmos-implementations-11-4-0/10.html
As an aside you can, (and many large customers who are using NSX do) utilize VLANs for all the network segments within an NSX environment. VXLAN is not a requirement for an NSX environment, but rather an optional feature.
Paul