F5 SSL Pass Through from SCCM IBCM to back end DMZ server.

If you configure the VS to just pass the IP traffic back & forth like a router (With or without (S)NAT) then it should work fine.

It isn't as if the bigIP 'looking' at the cert 'breaks' it... It's because your BigIP is be acting as an SSL endpoint. i.e. A Man In The Middle. SSL/TLS is DESIGNED to break when this happens. It's part of the security.