The unit supports vCMP, but if you not running vCMP is like any other unit.
Here is the platform guide for 5000 series:
https://support.f5.com/content/kb/en-us/products/big-ip_ltm/manuals/product/platform-b5000/_jcr_content/pdfAttach/download/file.res/Platform_Guide__5000_Series.pdf
The unit has RJ45 port for failover, and that can be used.
As far as I know, the only unit that does not support hardware failover is VIPRION (but it does have failover port :P).
This solution have all information you may need about configsync and mirroring options.
https://support.f5.com/kb/en-us/solutions/public/14000/100/sol14135.html