Inline load balancing and "Loose Initiation" & "Loose Close"

But i was suggested to enable also "Loose Initiation" & "Loose Close" but not really sure if we need it.

This configuration accepts traffic and forwards it using the information contained in the system routing table, regardless of whether it is associated with an established connection.

sol7595: Overview of IP forwarding virtual servers

http://support.f5.com/kb/en-us/solutions/public/7000/500/sol7595.html

if it is not the case, you do not need to enable loose initiation and loose close configuration.