The stream profile was actually blank. I wanted the flexibility of leaving it up to the iRules to define where and what gets rewritten. I've just had some instances where things overlap between these virtual servers.
The iRule itself is where the find/replace operations were defined.
Looking back, I think I know what happened. I had the iRule on all virtual servers originally and removed it from the production environment. I'm guessing the configuration settings were still being cached when I was doing testing. It appears to be working normally now. I usually run a config sync to trigger the config to reload when I'm done making changes.
Nimbostratus