Is there a way to trigger an iRule twice?

Ahh. Ok. I tried to format the response like a request in hopes that it would trigger the http_request event on the sideband. So should I do that in an http_response event in the irule associated with the sideband (aka irule B)? If I do the tcp layer method, can I still change the uri when it hits the sideband? I'm not too familiar with the procs. I'm running 11.3 and thought it was an 11.4 and newer feature.