NimbostratusWhat access protocols are you using Colin? IP-HTTPS, Teredo?
The persistence method is what is causing the clumping. Dest_addr is best used when load balancing transparent devices, such as a routers. I would definitely recommend changing that. In my testing, I did not see a need to set persistence. If you do set it, I would recommend setting it to source IP. Cookie will not work, as the BIG-IP is not able to inspect the payload (without doing SSL termination/re-encryption, which is not currently supported by MSFT for Direct Access).
My recommendation would be to use Least Connections for the load balancing method, and no persistence.
Changing lb & persistence methods should not have an effect on existing connections. They will continue without disruption.
NimbostratusYou would need persistence for Remote Manage Out, else your would be constantly flipping between server connection Servers all day.
Also depending on how many clients you have this might risk port exhaustion with all this flip flopping about.
