What does the websphere_tcp profile look like? Is the client base on the WAN on LAN? We have tuned the default profile somewhat for our WAN clients, the values we have changed are below:
proxy mss enable
slow start disable
bandwidth delay disable
nagle disable
proxy buffer low 98304
proxy buffer high 131072
send buffer 65535
recv window 65535
FYI, enabling bandwidth delay can create instability on your standby unit if you mirror L7 traffic. CR67185 was created for this, unfixed as of this point.
Feel free to contact me offline if you need further assistance as the performance issue you are tracking down isn't rules related.