Hi, sorry for the late answer.
There will be two one connect profile, one for SNAT (/24) and other without SNAT (/32), in one http request there are multiple connections, thats why we need to use oneconnect.
In fact, we migrate a couple of vserver from Cisco CSM with persistence-rebalance to our F5 without oneconnect profile, and the connections were four times higher.
i was testing with a vserver, and with oneconnect profile and no persistence profile, i always get a 402 answer from my http server, but if i add a persistence profile like source address, works fine, but i cant use source address because there will be a lot of connection using only one server for forever, with cookie persistence its kinda weird the behavior, but there is a KB where indicates that we have to use an irule to solve this (an ugly solution i think).
Checking the configuration in the cisco CSM, i was looking for persistence profiles or something like that, but only use "persistence-rebalance" no source address, or cookie or something.
im going to continue with the lab and see if something is missing.
Thanks!
Felipe.