Is this an issue with your modifications using iControl? Or is it using the product GUI? I'm not aware of any lag time issues outside of the fact that persisted connections will likely not get the changes in the profile - I could be wrong on that one though as I don't know specifically with regards to compressions.
This is really a question better suited for Product Support as it falls outside the realm of developer API types of questions so you might get faster results there.
If anyone out there knows the answer, please chime in. You might try posting this to the Adv Design and Config forum to see if any other eyes can help you out.
-Joe
Nimbostratus