protocol profile server - use client profile

sims2009, it's not necessarily a question of type of Virtual Server, rather a question of type of traffic patterns. Quite often client traffic is over the internet, with high latency traffic, so tcp-wan-optimised is useful, and on server side it's internal, low latency traffic, so tcp-lan-optimised is better (note i've made a sweeping generalisation here!).

I would focus on the traffic patterns first and then the protocol profiles for port both 80/443 VSs may be the same. See the following useful articles:

Investigating the LTM TCP Profile

Stop Using the Base TCP Profile!

In answer to your second question, use client profile means just use whatever protocol profile is in use for clientside.

Hope this helps, N