STP and LACP best practices

LACP is needed if you want to setup a PortChannel to the Nexus (Trunks in F5 terms), You can make it active or passive. I will suggest Active. Please leave the LACP LB as "Src/Dst IP and Port". It works in most scenarios. or you change to what suits for your network. For STP you can leave the default on the F5 box but manually Prune allowed vlans on the Nexus Portchannel to the F5.

HTH