1:should I enable UIE profile in default persist profile,why?
I see we use it via irule,why should enable it in default persist profilei do not know but i think it is not different between specifying irule in universal profile and assigning irule to virtual server. anyway, i always assign irule to virtual because not only persistence i do in irule. so, i think it makes more sense to assign it to the virtual.
2:should I enable oneconnect profile while using UIE ?
why?i think you should if you want to reduce a number of connection toward server.
just my 2 cents.