I too am curious how to accomplish this. I have users at site A who access resources in site B. Site A has a big IP but users at site A are not currently using it for this particular resource but rather are using the big ip at site b which is not local to them. Ideally I would prefer users at site A to use the big ip local to them in order to take advantage of compression and caching on an appliance local to them. The answer below says ensure there is a route to the pool member and back to the big ip. My understanding was that a self IP must be assigned to each big ip that resides on the same subnet as the pool member you are load balancing. Then in the virtual server configure snat or automap which would then use this ip.
Nimbostratus
