Forum Discussion
If you're out of ideas, you can try implementing a few changes I have listed below. The app is already broken and unavailable anyway, right :)?
Personally, I'd start by enforcing the use of TLSv1.0 (seen as SSLv3.1 in SSLdump utility) on the serverssl profile you use for this particular Virtual Server. I have seen a number of issues with incapable end-servers that do not respond/downgrade if SSL handshake's ClientHello from BigIP comes in with a version that is not supported. A SSL handshake problem on the serverside is one of the possible reasons for receiving a TCP/RST on the clientside.
Another idea. Since your issue is occuring sporadically, it could be that your problem is isolated to one of the end-server listener ports, and not both of them. Try disabling port TCP 8888 listener Pool Member(s), and see if the issue can be reproduced. Repeat vise-versa with the other Pool Pembers.
Just a few ideas on how to continue.
Good luck,