How to run Rest API call followed by Sync. What are the best practices for this?

In our environment we have an active/standby setup. I'm currently using the Python module BIGSUDS to make REST API calls to our BIGIP LTM. I have a script that enables and disables nodes within our pools. Every time the script is run and a node gets enabled/disabled the active LTM gets out of sync. I'm currently only making a REST call to the active node.

This is a problem as we have to continually sync the active/standby pair. What is the best practice for me to make these REST calls without needing to do a sync ever time? If I perform REST calls to both active/standby will this resolve the issue of sync status-pending?